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This human failing has caused many physicians and patients to reject 5-alpha reductase inhibitors because they recall something about more high-grade prostate tumors in men taking Proscar[R] or Avodart[R].
Schellhammer has received research funds or support from Glaxo-SmithKiine, which markets the 5-alpha reductase inhibitor dutasteride, and from other pharmaceutical companies.
Using data from the National Health and Nutrition Examination Survey (NHANES) for 2003-2006, the researchers assessed associations between medication use and log-transformed PSA levels in 1,846 men aged 40 years or older who had a serum PSA measurement; did not have a history of prostate cancer, prostatitis, or recent prostate manipulation; and were not taking 5-alpha reductase inhibitors or hormone therapy.
alpha-blockers, 5-alpha reductase inhibitors, antimuscarinics) and physiotherapy.
Urologists estimated that 28% of patients using some alpha-blockers -- which work by relaxing the muscles in and around the prostate -- experienced difficulties with ejaculation versus 16% of patients using 5-alpha reductase inhibitors (5-ARIs) -- which work by shrinking the prostate.
In the treatment of benign prostatic hyperplasia (BPH), there are several widely utilized medical therapies such as alpha-blockers and 5-alpha reductase inhibitors and occasionally antimuscarinics that have become standard therapies in the clinical practice guidelines.
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