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Alisertib (MLN8237), a selective AURKA inhibitor, induced a treatment response in six out of 35 patients (17%) with relapsed/refractory AML, while 49% achieved stable disease.
Yorkshire) (2012) 17 Composite population AURKA, Schneider et al.
and Europe concluded that the majority of neuroendocrine prostate cancers significantly overexpressed AURKA and MYCN genes, and 40 percent of these tumours also had extra copies of these genes.