Because pafuramidine is more user-friendly than existing therapies, we anticipate that it would be available in community clinics as well as at current African sleeping sickness
Neglected diseases such as African Sleeping Sickness
, Leishmaniasis and Malaria, represent a major economic burden on developing countries.
The FDA has also granted to pafuramidine's African sleeping sickness
indication Fast Track and Orphan Drug status, which is expected to accelerate review and provides for waiver of the Prescription Drug Users Fee.
1 million from a scientific consortium led by the University of North Carolina at Chapel Hill (UNC), which received funds from The Bill & Melinda Gates Foundation (the "Gates Foundation"), to develop drugs for fighting African sleeping sickness
(trypanosomiasis) and leishmania.
Immtech's most promising compound, DB289, is currently in development for the treatment of malaria, pneumocystis carinii pneumonia (PCP), and African sleeping sickness
SEATTLE -- Beginning today, Seattle Biomedical Research Institute (SBRI) is hosting a landmark international scientific conference, the 2004 TriTryp Genomes Meeting, which will bring together experts from around the world to discuss the first drafts of the genome sequences for three parasites that cause deadly infectious diseases including leishmaniasis, Chagas disease and African sleeping sickness
And the agency's reaction to those applications will give antisense companies their best clue yet about the regulatory hurdles they can expect as they seek approval for oligos aimed at a variety of diseases, including influenza, cervical cancer and African sleeping sickness
He is also a member of the Board of the South South Initiative (SSI) of the World Health Organization Special Program for Research and Training in Tropical Diseases (WHO - TDR), and the coordinator in the field of Trypanosomiases, including Chagas Disease and African Sleeping Sickness
Piet Borst and his colleagues at the Netherlands Cancer Institute in Amsterdam report similar success in using the neomycin gene to replace a targeted gene in Trypanosoma brucei, which causes African sleeping sickness
Subsequent to September 30, 2007, a payment of $5,123,000 was received to further the development of pafuramidine, the Company's oral drug candidate, in the Phase III African sleeping sickness
Existing treatments for African sleeping sickness
that were developed over the past 80 years can cause severe side effects.
The 10GB winning project in Europe, led by Pascal Maser from the Swiss Tropical Institute (formerly University of Bern), together with Harry de Koning from the University of Glasgow, will use the sequencing award to uncover low-frequency genetic mutations in the parasite species Trypanosoma brucei subspecies which causes African sleeping sickness