Also known as the water channels in living cell membranes, aquaporins
have been found to be the functional unit of nature's water purification systems.
4 is expressed in supporting cells, such as astrocytes and ependyma, especially in the interface between major fluid compartments and brain parenchyma, but it is not expressed in neurons.
To establish the molecular weight of the target protein, ensure specificity of binding of the anti-aquaporin
antibody, and to detect the presence of aquaporin
-like proteins in gametophytes, an antibody against maize PIP1 aquaporin
was raised using a homologous sequence from previously mapped aquaporins
in maize (Chaumont et al.
Molecular characterization of an aquaporin
cDNA from brain: candidate osmoreceptor and regulator of water balance.
During the 1990s, scientists identified and characterized members of the mammalian aquaporin
family, now designated as AQP0 through AQP10.
are critical for getting water into and out of cells.
The nine target genes were acyl-CoA synthetase long-chain family member 6 (ACSL6), apolipoprotein A-I (APOA1), PLTP, GK, CPT2, aquaporin
7 (AQP7), acyl-Coenzyme A oxidase 1 palmitoyl (ACOX1), ACOX2, and FABP4.
The purpose of present study is thus to assess the neuroprotective effects of the ginsenoside Rg1 against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion, and then to explore the mechanisms for these neuroprotective effects by targeting aquaporin
gene expression in arbuscular mycorrhizal Glycine max and Lactuca sativa plants in relation to drought stress tolerance.
He was awarded the Nobel Prize for discovering aquaporin
, the structure that allows water molecules egress across semipermeable membranes.
In addition, CaSRs are found on the luminal membranes of the collecting duct cells, and their activation reduces expression of aquaporin
2 water channels.
Neonatal ureteral obstruction alters expression of renal sodium transporters and aquaporin