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Use of HT in women with BRCAl and BRCA2 mutations requires further investigation.
Interestingly, when the comparison analysis was carried out in individual histological subtypes, the researchers observed that in the three clear cell ovarian tumors that carried deleterious BRCA1 or BRCA2 mutations, all expressed ER, while in the BRCA1/2 wild type clear cell tumors, only 3% (2/61) showed ER expression (p=0.
The phenomenon that each of these scores attempts to measure is now termed homologous recombination deficiency (HRD), being the biological state generated by loss of two functional copies of a homologous recombination gene such as BRCA1 or BRCA2.
Professor Paul Workman, deputy chief executive of the Institute of Cancer Research, said: "These findings indicate that around a quarter of smokers with a specific defect in their BRCA2 gene will develop lung cancer - a disease which is almost invariably fatal.
All sites also detected the most prominent single-exon skipping events not seen in controls for each of the unequivocal variants, apart from site 4 and 14, which did not detect the [DELTA] 20 transcript for the unequivocal variant BRCA2 C.
Every time I know or hear of a Jewish woman who developed breast cancer because of a BRCA1 or BRCA2 mutation, I think, "Why didn't we get the word out earlier?
Defective BRCA1 and BRCA2 genes also account for about 10% of ovarian cancers.
Lead researcher Professor Ros Eeles, from the Institute of Cancer Research, in London, said: "Our study shows that men diagnosed with prostate cancer at a young age have a higher chance of carrying a faulty BRCA2 gene.
We describe 3 patients with prostate cancer and an inherited mutation in BRCA2 who were treated with precision RT or chemotherapy (i.
This paper reports on women with proven inherited disease-predisposing BRCAI and BRCA2 mutations participating in the Prevention and Observation of Surgical Endpoints (PROSE) consortium multicentre study, who were ascertained to carry the high-risk predisposition gene between 1974 and 2008 [1].
Scientists from Manchester and Birmingham, UK, tracked 321 families with faulty BRCA2 genes to pinpoint the risk for men who have the mutation.
A faulty copy of the gene - called BRCA2 - causes hundreds of UK cases of breast cancer in women every year, and can be passed on to both sexes through the generations.