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The diagnosis of CML in blast crisis may not have been made or may have been further delayed if not for the detection of the myeloid sarcoma in this otherwise asymptomatic patient.
The presence of trisomy 19 as a new finding in a patient with a known diagnosis of CML is usually seen in patients with accelerated or blast crisis of CML.
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia.
The cells soon fill the bone marrow and spill into the bloodstream, a tell-tale sign that the disease has advanced to the blast crisis stage.
Its occurrence usually signifies the transition from the chronic phase of CML into an accelerated phase or, at worst, into a blast crisis.
9/L --> 15% blasts in peripheral blood --> 20% basophils and eosinophils in peripheral blood Blast Crisis Phase * > 30% blasts and promyelocytes exist in peripheral blood or marrow.
So far in humans, it appears that only CML cases that progress to lymphoid blast crisis (a marked increase in immature cells) or patients with Philadelphia chromosome-positive ALL are at risk for CNS leukemia," he said.
Gleevec is now approved for the treatment of patients with all 3 phases of CML-CML myeloid blast crisis, CML accelerated phase, and CML in chronic phase, either before or after use of other therapy.
C,, has received the Health Canada approval of Gleevec(x) (imatinib mesylate), an oral therapy for the treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated phase or chronic phase after failure of interferon-alpha therapy (a current standard therapy).
The end stage of the disease, known as blast crisis, can be fatal within several months, researchers said.
According to Radich, the disease progresses from the chronic phase into an accelerated phase, and then into the blast crisis phase, the terminal phase of the disease during which it has the greatest resistance to treatment.