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crisis
(redirected from Blast crisis)

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Imatinib mesylate, an inhibitor of Bcr-Abl tyrosine kinases, has revolutionized the treatment of chronic myelogenous leukemia (CML), showing marked improvements in survival in all three phases of the disease: chronic, accelerated, and blast crisis (see Figure 1).
4,11) In view of Philadelphia chromosome positivity and the patient's age, it might be suspected that the patient had CML presenting in blast crisis.
So far in humans, it appears that only CML cases that progress to lymphoid blast crisis (a marked increase in immature cells) or patients with Philadelphia chromosome-positive ALL are at risk for CNS leukemia," he said.
 
 
 
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