Among these factors, tubular ectasia and Sertoli cell dysgenesis might play a role by disrupting the blood-testis barrier, allowing antigens to enter the testicular interstitium and giving rise to an autoimmune process.
The human blood-testis barrier in impaired spermatogenesis.
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Regulation of blood-testis barrier
dynamics by TGF-[beta]3 is a Cdc42-dependent protein trafficking event," Proceedings of the National Academy of Sciences of the United States of America 107(25): 11399-11404.
TGF-[beta]3 and TNF[alpha]perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis," Developmental Biology 327(1): 48-61.
An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis," Proceedings of the National Academy of Sciences of the United States of America 105(26): 8950-8955.
Rat models with inducible gene expression can also be produced using SBI's SparQ(TM) cumate switch system, the first inducible system that can be induced with a small molecule that can readily cross the blood-brain and blood-testis barriers