The Company is utilizing these discoveries, along with its increased understanding of the structure-activity relationship of IRHs, to develop further compounds in this area, several of which are now being tested in animal models of bone marrow suppression
The bone marrow suppression
was more pronounced during CHOP therapy than during administration of BEXXAR.
The principal dose limiting toxicity of BEXXAR in clinical trials was generally reversible bone marrow suppression
that could be prolonged and severe and required supportive care in approximately a quarter of the patients.
These studies also suggest that Reverset does not produce mitochondrial toxicity, a common side effect associated with certain nucleoside reverse transcriptase inhibitor (NRTI) therapies that can lead to fairly serious and life-threatening bone marrow suppression
Talampanel, administered orally, has been well tolerated and has not caused bone marrow suppression
and other side effects of most current forms of cancer therapy.
Cytarabine is highly toxic with severe side effects including cerebellar toxicity and bone marrow suppression
However, the most harmful complication is bone marrow suppression
Regular monitoring is required for both treatments, particularly methotrexate to prevent significant bone marrow suppression
Adverse effects associated with long-term linezolid use included bone marrow suppression
and peripheral and optic neuropathy.