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Keywords: Tanshinone IIA Blood-brain barrier Brain edema Middle cerebral artery occlusion
Brain edema and disorders of intracranial pressure.
Compared to placebo, THR-18 significantly decreased the number of AIS patients with brain edema and intracranial hemorrhage.
DIH may lower the cerebral capillary permeability, cerebral index, and cerebral water content in rats with cerebral ischemia, thus attenuating brain edema induced by brain ischemia (Zhang et al.
13,23,50,65,67] The interaction of systemic (eg, hypotension, ischemia, abnormalities of temperature, electrolytes and osmolality) and intracranial events (eg, intracranial hypertension, brain edema, hydrocephalus, seizures and alterations in cerebral blood flow), may amplify the destruction of secondary injury, complicate clinical management and adversely affect outcome.
Patients undergoing craniotomy for malignant glioma and implantation of GLIADEL Wafer should be monitored closely for known complications of craniotomy, including seizures, intracranial infections, abnormal wound healing, and brain edema.
THR-18 is novel drug-candidate designed to reduce or neutralize the life-threatening adverse effects of tPA, such as intracranial hemorrhage (ICH) and brain edema.
Nasdaq: NTII) ("NTI") today announce the close of Celtic Pharma's acquisition of exclusive worldwide rights to XERECEPT(R), a Phase III clinical compound for the treatment for Peritumoral Brain Edema.
30] Furthermore, free radical scavengers such as superoxide dismutase (SOD),[12] dimethyl sulfoxide,[10] ONO-3144,[42] MK1-186[1] and dimethylthiourea[45] have been shown to also reduce experimental BBB breakdown and ischemic brain edema.
Aquaporins have been implicated in multiple clinical disorders, from fluid retention, to brain edema, to obesity.
Patients undergoing craniotomy for malignant glioma and implantation of Gliadel should be monitored closely for complications of craniotomy, including seizures, intracranial infections, abnormal wound healing, and brain edema.
The Company sold the rights and assets of Xerecept[TM] for the treatment of peritumoral brain edema while it continues to sponsor and conduct pivotal Phase III clinical trials.