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Klein showed that the cells destined to become oligodendrocytes and repair myelin damage, known as neural precursor cells, have high levels of the CXCR4.
Trofile is now 100% sensitive at detecting CXCR4 minor variants as low as 0.
The Quest Diagnostics laboratory-developed test used in the study employed triplicate population sequencing (TPS), which involves genotyping the third variable (V3) loop, a region of the virus that binds to the CCR5 or CXCR4 co-receptor, and bioinformatics, to infer tropism in patients harboring R5, X4 or dual-mixed virus.
Abstract # 47 Creating an HIV-resistant Immune System: Using CXCR4 ZFN to Edit the Human Genome (Presenter C.
TG-0054 demonstrated potent and selective antagonistic activities against CXCR4 in vitro.
An exception is the angiogenic ELR(-)CXC chemokine stromal cell-derived factor-1 (CXCL12/SDF-1), which binds to CXCR4 and CXCR7 and is implicated in tumor metastasis.
CXCR4 is a seven-transmembrane, G-protein-coupled receptor in the CXC chemokine receptor family that is expressed on a variety of cancers including leukemias, lymphomas, breast, lung, colon, pancreatic, and ovarian cancer.
Trofile is a clinically validated patient selection tropism assay that determines whether a patient is infected with a strain of HIV that uses either the CCR5 coreceptor, the CXCR4 coreceptor, or a combination of CCR5 and CXCR4 to enter cells.
The company is concentrating its efforts on the development of the cancer drug BKT140, designed to modify the activity of the chemokine receptor CXCR4.
The Trofile assay is now capable of detecting CXCR4 tropic virus existing at levels as low as, or in some cases lower than, 0.
The paper, entitled "Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells" by Boris Tchernychev and Yong Ren et al.