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fibroblast growth factor-2 (FGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF) bind to specific cell-surface receptors and initiate an intracellular signal transduction cascade involving the sequential phosphorylation of Ras, Raf, Map kinase kinase (MEK), and ERK.
This protein is the primary cell-surface receptor that is commandeered by HIV, which uses it to enter white blood cells.
DCC codes for a cell-surface receptor that binds to netrin-1, which scientists had previously linked to nervous system development.
In healthy people, Prp acts as an ordinary cell-surface receptor, but its function is not clearly understood.
Both companies are testing hybrid molecules composed of the natural cell-surface receptor for TNF coupled to the back end of an antibody.
Takao Shimizu at the University of Tokyo, with colleagues there and at the Protein Engineering Research Institute in Osaka, has cloned the cell-surface receptor for a blood compound called platelet-activating factor (PAF) -- one of the body's most potent alarm chemicals and the one responsible for much of the biochemical mayhem underlying asthma attacks and other inflammatory reactions.
In 1988, researchers isolated and inserted into cultured cells the gene for a cell-surface receptor called D2, which responds to dopamine by inhibiting certain chemical reactions inside cells.