An association study between the Clara cell
Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell
70,93) The existence of a putative bronchioloalveolar stem cell, likely corresponding to the variant Clara cells
, has been suggested by experimental studies to be located at the bronchioloalveolar duct junction.
We exposed murine Clara cells
, which are known to express functional Nat2, the murine ortholog of human NAT1 (Kawamura et al.
These findings suggest that Clara cell
injury by bioactivated chemicals in the developing animal is not necessarily predicted by the level of CYP450 enzyme activity.
Inhaled naphthalene causes dose dependent Clara cell
toxicity in mice but not in rats.
In the terminal bronchioles, ciliated and Clara cells
begin invading the alveolar airspace.
The researchers theorize that repeated exposure to disinfection by-products around indoor swimming pools may damage Clara cells
, decreasing production of CC16 and possibly masking any effect that ozone exerts on CC16 levels.
urea and sweat) in pools may decrease the CC16 secretion because of Clara cell
dysfunction or damage.
In the present study, we investigated the role of Clara cells
in inflammation and fibrosis in vivo by exposing Clara cell
-ablated mice to crystalline silica, which is known to cause pulmonary fibrosis (30-33), and examined the gene expression of MMP-2 and MMP-9 in lung tissue using reverse transcription-polymerase chain reaction (RT-PCR).
The Clara cell
protein, CC16: a biomarker of pulmonary toxicity.
The FGF caused the variant Clara cells
to revert to their original stem-cell state.