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MA as a competitive inhibitor prevents the binding of the substrate by binding reversibly the active site of CYP3A4 enzyme.
Dihydrotanshinone was not only a potent competitive inhibitor of human CYP1A2 and CYP2C9, but also a potent noncompetitive inhibitor of human CYP3A4.
P93/01 is an orally active, competitive inhibitor of DP-IV that is designed as a shorter-acting inhibitor.
In more recent studies, it has been shown that SPC3 behaves like a competitive inhibitor of HIV-1 entry into epithelial cells that are either devoid of CD4 receptors or express Cal/Cer receptors.
Preclinical in vitro data shows that HCI-1401 is several times more potent in inhibiting BTK than other competitive inhibitors.
A wide variety of state-of-the-art technologies will be applied, including: (i) innovative chemical approaches for the design, synthesis and engineering of peptide and protein biosensors, (ii) biochemical, biophysical, and fluorescence-based approaches for characterization of the sensitivity, specificity and physicochemical features of the biosensors, (iii) cell biology and fluorescence imaging approaches for characterization and validation of these biosensors in cellulo and in vivo, (iv) application of fluorescent biosensors for development of diagnostic assays, and (v) application of fluorescent biosensors for development of high throughput screening assays and identification of selective non-ATP competitive inhibitors for cancer therapeutics.
Current approaches to neutralising chemoresistance have centred on developing competitive inhibitors.
These drugs also are competitive inhibitors of histamine receptors, both [H.

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