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complement |
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complement noun companion, complementum, completion, congener, coordinate, correlate, corresponding part, counterpart, pendant, reciprocal, remainder, rest, supplement See also: accession, addendum, addition, adjunct, allonge, appendix, boom, codicil, component, content, corollary, correlate, correspond, increase, rider, staff, structure, supplement How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| This complement cascade eventually results in the formation of a membrane attack complex, a multiprotein assemblage that latches onto the surface of endothelial cells, killing them directly or, more often, activating them. By blocking the two key pathways of complement activation (the C3 and C5 convertases) early within the complement cascade, MLN2222 may reduce tissue injury in multiple organ systems, reducing the mortality and morbidity associated with CABG surgery employing CPB. In contrast to APT070, which acts early in the complement cascade, CD59-Prodaptin(TM) interrupts the formation of the "membrane attack complex" which is responsible for killing cells. |
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