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This retinoid-like ingredient activates the proliferation of keratinocytes and inhibits the differentiation of corneocytes. This pattern is most prominent in larger nests and lobules and consists of centrally located plugs containing degenerate hydropic cells, parakeratotic corneocytes, or tumor necrosis. 4, A and B, shows green autofluorescence of the stratum comeum with the typical polygonal structures of corneocytes. |
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