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cGMP is an important second messenger which mediates the response of the cell to extracellular stimulus through the activation of protein kinase G (PKG), cGMP-phosphodiesterases (PDEs) and cyclic nucleotide gated ion channels (CNG). Cyclic nucleotide PDEs consist of 11 gene families, each having one or more different members or "isoforms. Cyclic nucleotide PDEs consist of 11 gene families, each having one or more different members or "isoforms. |
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