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Mutation
(redirected from De novo mutation)

   Also found in: Dictionary/thesaurus, Medical, Encyclopedia, Wikipedia 0.01 sec.

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.



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Most affected individuals have inherited the mutation from one of their parents, but rarely it can be caused by a de novo mutation.
In total, we have observed the identical deletion of nearly 600 kb [kilobase] in 13 subjects with autism or developmental or language delay (10 confirmed de novo mutations, 2 confirmed inherited mutations from parents with ADHD or mental retardation, and 1 mutation of unknown inheritance), with the reciprocal duplication of the same region documented in 11 additional subjects," said Dr.
8) A recent report has documented the presence of a de novo mutation of the Notch3 gene in a patient with no family history and absence of mutation in both biological parents.
 
 
 
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