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Related to Dopamine receptor: dopamine receptor D2
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The D2 dopamine receptor gene as a determinant of reward deficiency syndrome.
Mostly, the underlying cause has been assumed to be antipsychotic drugs and other dopamine agonists, and the phenomenon of dopamine receptor hypersensitivity in the nigrostriatal dopamine pathway has been emphasized (2).
Medications may cause galactorrhea by blocking dopamine receptors, depleting dopamine, inhibiting dopamine release, blocking histamine receptors, or stimulating lactotrophs.
In the setting of increased dietary sodium intake, renal dopamine receptors regulate >50% of sodium excretion (12).
These findings confirm and extend those of several previous reports in the literature, but none of the dopamine receptor agonists--pramipexole, ropinirole, cabergoline, bromocriptine, rotigotine, and apomorphine--currently carry a boxed warning about the potential for developing severe impulse control disorders.
Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism.
Chen said that one surprising finding is that many genes required for glioblastoma growth are also required for dopamine receptor function.
Blocking these receptors may be a way to treat motor symptoms, when sufficient dopamine receptor stimulation is no longer possible.
It has been shown that dopamine receptor type 2 (D2) encoded by DRD2 gene (OMIM rs1800497) is involved in liability to different types of addiction: alcohol, nicotine, cocaine and heroin [4].
All antipsychotic drugs currently in use are predominantly blockers of the D2 dopamine receptor, which effectively reduces dopamine's effects on the brain (Stahl 2008: 273).