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Understanding the basics of PD and PK interactions in the setting of patient-specific factors can help to clarify the information found in drug-drug interaction databases, such as Micromedex, Lexicomp, Facts and Comparisons, and Epocrates.
Are there clear recommendations for management of drug-drug interaction (for example, adjustment of dosing regimen), that is, whether the drug-drug interaction was considered clinically significant.
But not much is known about how these first-line regimens compare in rates of drug-drug interactions.
These results will further help us to identify and prevent dangerous drug-drug interactions in humans and to understand how drugs are metabolized and disposed of.
The UM/PCPS criteria included drug-drug interactions, therapeutic duplications, and high daily dose for eight classes of drugs: angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, cardiac glycosides, benzodiazepines, antidepressants, antipsychotics, histamine-2 receptor antagonists (H2RAs), and non-steroidal anti-inflammatory agents (NSAIDs).
Based upon Idenix's discussions with the Agency, the company is primarily focused on three cases of elevated liver function tests observed during its drug-drug interaction study of the combination of IDX184 and IDX320 in healthy volunteers, added Sommadossi.
of Maryland-Baltimore) with help from fellow scholars of psychiatry and medicine, uses a case vignette format to make drug-drug interactions both more interesting and more accessible to medical students and residents than typical textbooks do.
While there have been no other clinically significant reports of a drug-drug interaction between omeprazole and digoxin, we believe that this possibility should be considered in patients on digoxin therapy who require treatment with a proton pump inhibitor.
The database currently tags 136,000 individuals working in Drug-Drug Interaction.
A clinician who understands pharmacodynamic interactions will be able to better identify potential drug-drug interactions and could avoid adverse events.
This study aimed at the assessment of the awareness and knowledge of the community pharmacists about drug-drug interactions.
9) Otherwise, the burden of drug-drug interaction, in terms of patient's safety, may be reduced by preventing concomitant use of potentially interacting drugs and, whenever possible, by replacing drugs at interaction risk with effective but safer alternative medications belonging to the same drug class.