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Statistical analysis that weighed the impact of several factors that may cause drug-drug interactions found three factors that caused such interactions regardless of all other factors (Figure 1).
In a separate oral presentation at CROI, investigators described the results from three open-label Phase 1 studies in healthy volunteers that evaluated the drug-drug interactions of faldaprevir with the common HIV medications darunavir/ritonavir, efavirenz, or tenofovir.
As these two compounds are only considered minor substrates of this particular enzyme, drug-drug interactions between digoxin and omeprazole have been deemed of limited clinical significance.
Leading organisations in Drug-Drug Interaction research include:
In this issue of the Southern Medical Journal, (13) authors describe a case report of drug-drug interaction in a 61-year-old patient who was chronically treated with atorvastatin (plus ezetimibe and niacin) and antiseizure drugs, phenobarbital and phenytoin.
Preclinical and Phase 1 clinical data indicate a low propensity for drug-drug interactions
The Company's software applications include a web-based query tool, AurQUEST[R], a compound profiling visualization interface, AurPROFILER[R] and a Drug-Drug Interaction predictive application, DDI Predict [R].
Called the Drug-Drug Interaction Module (DDIM), the new technology is free to all current and future MedAppz iSuite users and is available immediately.
Results Demonstrate Utility of CellPort Technologies in Predicting Drug-drug Interactions
This collaboration will accelerate the implementation of what we expect to be the most advanced drug-drug interaction capability in the industry.
This exhaustive knowledge database contains all relevant biological and chemical information related to the metabolic properties of drugs and assists in the identification of potential drug-drug interactions.
Each drug-drug interaction monograph will display the name of each drug that results in the interaction, the severity level for the interaction, a statement on how the interaction occurs, possible effects of the interaction, information on what to do about the interaction and references.