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In the present study the ED50 of intrathecal hyperbaric bupivacaine for successful anaesthesia and the highest levels of sensory and motor blocks did not differ between the two patient cohorts, although time to first request for supplemental analgesia and first self-voiding were significantly prolonged in obese patients.
At the 7th Annual Meeting of the Oligonucleotides Therapeutics Society in September 2011, Alnylam presented pre-clinical data from its ALN-APC program showing dose-dependent silencing of the protein C mRNA with an ED50 of 0.
Pre-clinical data from the ALN-PCS program have shown specific silencing of PCSK9 mRNA in the liver and reduced plasma PCSK9 protein levels of up to 90%, with an ED50 (the dose that provides a 50% silencing effect) estimated at approximately 0.
reLNPs demonstrate potent target gene silencing in vivo, with an ED50 (the dose that provides a 50% silencing effect) at doses of less than 0.
Pre-clinical data from the ALN-PCS program have shown specific silencing of PCSK9 mRNA in the liver, and plasma PCSK9 protein levels of up to 90%, with an ED50 (the dose that provides a 50% silencing effect) of approximately 0.