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Interactions of eukaryotic elongation factor 2 with actin: a possible link between protein synthetic machinery and cytoskeleton.
Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2.
The gene family encoding the Arabidopsis thaliana translation elongation factor EF-1 alpha: molecular cloning, characterization and expression.
Fruitflies with additional expression of the elongation factor EF-1[Alpha] live longer.
The researchers also noticed a resemblance between the astounding manner in which the poxA gene modifies the bacterial elongation factor to regulate stress resistance, and the way a similarly acting factor is regulated in plant and animal cells.
The expression levels of 3-hydroxyacyl-CoA dehydrogenase type-2 (HCDH), acetyl-Coenzyme A acetyltransferase 2 (ACAT) and elongation factor Tu were down-regulated, and alpha-enolase and creatine kinase were up-regulated in the livers of ketotic cows.
Abbreviations: BiP, binding protein; eEF1A, elongation factor 1A; DAA, days after anthesis; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Among the known mRNAs analyzed so far were ferritin light chain, eukaryotic elongation factor alpha-1 and kinesin light chain.
Some of the identified targets are: Caspase 3, Colony stimulating factor 2, COX, Cyclin-dependent kinase inhibitor 1A, DNA (cytosine-5-)-methyltransferase 1, Epidermal growth factor receptor, Eukaryotic translation elongation factor 1 alpha 1 etc.
The top-half domain, sometimes referred to as a tRNA "minihelix," has been shown to provide the determinants necessary for specific charging by aminoacyl tRNA synthetases (14, 15); for interaction with elongation factor Tu (16); for 5[prime] processing by RNase P (17); and for distinguishing elongator from initiator tRNA (18).
For example, we have shown that cladistic analysis (sensu Hennig) of the elongation factor protein data set does not support the rooting of the tree of life in the bacterial branch (4).
The SS1P molecule is an ingenious example of protein engineering: the native Pseudomonas exotoxin protein consists of three domains: domain I targets cell surface receptors, domain II functions to translocate the molecule across a cell membrane and into the cell interior, and domain III catalyzes irreversible ADP ribosylation and inactivation of elongation factor 2 (EF2).