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Related to Extrinsic pathway: Prothrombin time, APTT
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In the case of human leukemia cells, it involves activation of both the intrinsic and the extrinsic pathways of cell death and combined treatment with MEK1 /2 pathway inhibitors leads to enhanced cell death.
The anticoagulant effect in heparinized blood and plasma resulting from interactions with extrinsic pathway inhibitor.
One approach has aimed to block initial triggering of the extrinsic pathway by preventing cellular synthesis of Fas or FasL or by administering an inhibitor of Fas-FasL binding.
By targeting this pathway, rather than the extrinsic pathway, it is expected that TTP889 will provide protection from throboembolism with fewer of the bleeding complications associated with the use of existing anticoagulants.
Especially, the combined treatment with Baccharin and Drupanin, each used at an lC2o concentration, exhibited a significant synergistic growth-inhibitory effect through both intrinsic and extrinsic apoptotic signaling pathways, which effect was mediated by up-regulation of the levels of TRAIL and FasL, in the extrinsic pathway that function in an autocrine or paracrine manner.
Defects involving the extrinsic pathway are typically associated with an elevated PT but normal PTT.
Either the intrinsic or extrinsic pathway can activate the clotting process.
This form of apoptosis was found closely associated with the extrinsic pathway caspase (caspase-8) and inhibition of translocation of NF-[kappa]B from cytoplasm to nucleus.
The PT evaluates the extrinsic pathway of coagulation (factors VII, X, V, II, and fibrinogen).