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Variable and fixed large airway obstruction often gives rise to strikingly abnormal flow-volume loops.
The flow-volume loop measuring both FEV1 and FEF25-75 has been shown to be a reliable and simple test to document the very beginning of lung rejection in lung transplant patients.
In the helium iso-flow maneuver, after the patient has taken in the three large breaths of heliox, the flow-volume loop is recorded.

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