knockdown

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Related to Gene knockdown: Gene knockout

knockdown

verb accost, assault, attack, batter, be reckless in harming a person, beat, besiege, damage, deal a blow, harm, hit, hurt, inflict harm, inflict injury, injure, shruck off
Associated concepts: assault, battery, dart out case, hit and run
References in periodicals archive ?
For the second siRNA transfected (siRNA2), as shown in Figure 4C, small decrease in CYP19 gene transcript abundance was seen when transfected with 100nM siRNA (siRNA2) concentration, however, percentage gene knockdown achieved was only about 40 percent (Figure 4B).
This delivery strategy produces over 500-fold increase in efficiency in mice compared to injection of cholesterol-siRNA alone and is the first delivery system to demonstrate cholesterol-siRNA mediated gene knockdown in monkeys.
The subcutaneous DPCs have shown striking levels of target gene knockdown, which we are pleased to have the opportunity to discuss at the OTS meeting," said Bruce D.
PMCC is using Caliper's Staccato automation system to perform oncology related lab discovery experiments in less time, leading to a better understanding of how to treat and prevent cancer through gene knockdown therapies.
Importantly, DPCs display a low toxicity profile enabling siRNA redosing and long-term target gene knockdown.
This new tool is designed to eliminate the trial and error approach of identifying a single siRNA for gene knockdown and ensures minimal off-target effects.
They used a human siRNA library to perform a whole kinome screen, targeting 779 kinases and 80 cell cycle genes to analyze cell proliferation in real time, by monitoring the dynamics of the cellular responses after high-throughput gene knockdown.
Many of our researchers are interested in targeted gene knockdown on an individual or gene-focused basis, as well as a genome-wide scale for which we are fully equipped.