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Related to Germinal center: lymph node, mantle zone
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2014) B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.
Quantitative Assessment for Interstitial Lymphoid Aggregates and Germinal Centers
Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma.
11) It has been postulated that antigenic B-cell stimulation in the context of relatively preserved immune function, typical of the HAART era, could disproportionately promote germinal center pathways of lymphomagenesis.
Three gene expression subgroups are recognized: germinal center B-cell-like (Figure 1), activated B-cell-like, and type 3 or unclassfied.
These results were not specific enough to be considered diagnostic; however, germinal centers are present in 80% of borrelial lymphocytoma cases (12).
TH] cells provide critical assistance for follicular and germinal center B cells, inducing activation, differentiation, and antibody production.
The histopathology of this lesion resembled a follicle from a lymph node, and it contained a germinal center, a mantle zone, and a surrounding marginal zone.
For example, the poor outcome marker Bcl-2 more likely segregates with immunoblastic tumors of postgerminal center origin and predicts poor prognosis compared to the Burkitt's and centroblastic tumors, both of which are more likely associated with germinal center histogenesis and a better prognosis.
According to gene expression profile, DLBCL can be classified into two distinct subgroups: germinal center B-cell-like (GCB) group and activated B-cell-like (ABC) group.
Rodda is fascinated by what goes on in that gray oval, known as the germinal center.