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Vancomycin is a glycopeptide antibiotic isolated from Streptomyces orientalis.
Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci.
In addition to drug discovery activities, LEAD currently has two compounds in preclinical development: LT-673, a PARP inhibitor being developed for oncology indications; and LT-29, a glycopeptide antibiotic for gram-positive infections.
An electronmicroscopic study of glycopeptide antibiotic resistant strains of Staphylococcus epidermidis.
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.
LEAD will present the new glycopeptide antibiotic, LT-29, for the first time at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).