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They found that PPI users had a 26 per cent higher risk of developing chronic kidney disease compared to those who used H2-receptor antagonists and that there was also a correlation between PPI and acute kidney disease.
When H2-receptor antagonists are used for GERD, it is preferable to give split-dose twice daily or more frequently) therapy.
DUEXIS, a proprietary single-tablet combination of the NSAID ibuprofen and the histamine H2-receptor antagonist famotidine, also decreases the risk of developing upper gastrointestinal ulcers, which in the clinical trials was defined as a gastric and/or duodenal ulcer, in patients who are taking ibuprofen for those indications.
The blinded clinical trial compared Rapinex 40mg, administered through a nasogastric tube, with intravenous (IV) cimetidine, an H2-receptor antagonist and the only drug currently approved by the U.