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Other new therapeutic options and targets include neurosteroids, selective H1 receptor antagonists, H3 receptor agonists, and substance P.
Related conclusions come from an independentstudy by researchers at the University of Cincinnati's College of Medicine, who found the H3 receptor on nerve endings that surround blood vessels.
Ziarco's pipeline includes a histamine H4 receptor antagonist programme, with a lead compound that has completed a Phase 1 multiple ascending dose study; a clinical stage cytosolic phosholipase A2 (cPLA2) inhibitor; histamine H3 receptor antagonists possessing CNS-sparing properties, with a lead compound in advanced preclinical development; as well as early-stage spleen tyrosine kinase (SYK) inhibitor molecules suitable for topical administration.
The licensed programmes include Ligand's aplindore programme for the treatment of various CNS disorders, a CRTH2 antagonist programme for respiratory disorders, a Captisol-enabled acetaminophen programme for pain and fever management as well as an H3 receptor antagonist programme for the treatment of narcolepsy.