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As infeccoes oportunistas apos uso da terapia HAART ocorreram em 74 pacientes com maior prevalencia para herpes cutaneo em 18 (12,5%) pacientes, candidiase orofaringea em 14 (9,7%), pneumocistose em 12 (8,3%) e toxoplasmose em nove (6,25%), diarreias apareceram em 12 (8,3%) dos pacientes.
5%) of 237 patients with TB at baseline started on HAART had paradoxical TB-associated IRIS, while 12 (3%) of 390 patients without TB at baseline developed ART-associated TB after starting HAART.
We therefore concluded that an appropriate case definition for leprosy associated with IRIS in AIDS should include: leprosy and/or T1R and ENL developing within 6 months of starting HAART; advanced HIV infection; low CD4+ count before starting HAART and, CD4+ count increasing after HAART.
The pathogenesis of IRIS is poorly understood but is related to the recovery of the Th-1 immune response following successful suppression of viral replication by HAART.
The odds of contraceptive use were elevated more than twofold among women who were receiving HAART (odds ratio, 2.
In multivariable analysis of 4,892 births that controlled for therapy type, delivery mode, gestational age and sex of infant, women who had received no treatment had an increased risk of mother-to-child transmission compared with those who had received HAART, and women who had given birth to girls rather than boys also had an elevated risk of transmission (odds ratios, 9.
In an additional analysis involving the three main HAART drug classes, only nucleoside reverse transcriptase inhibitors were associated with decreased incidence of multicentric Castleman's disease.
The use of HAART has also led to increased reports of immune recovery uveitis (IRU), which behaves as an immune restoration disorder [10].
Although much attention has been focused on one or more HAART drugs as the inciting cause of HIV-associated lipodystrophy, its etiology is very likely muhifactorial.
The trend toward lower CD4-lymphocyte count at the start of HAART was also a point of concern, and "might have increased the risk of immune restoration syndrome," they said.