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While the association of Hodgkin disease with monoclonal gammopathy is rare,[2-6] the association with GHCD is extremely rare.
Cozzolino et al[15] described a 50-year-old woman with a history of nodular sclerosis Hodgkin disease who presented with GHCD, stage 2B.
The liver nodule and bone marrow biopsy showed involvement by Hodgkin disease (stage IVB).
After surgery, the patient continued to be febrile, with temperatures ranging from 102 to 105[degrees]F, which was attributed to Hodgkin disease.
Within the nodules were numerous Reed-Sternberg cells and their variants in a mixed inflammatory background (Figure, B), characteristic of Hodgkin disease.
All these clinical and laboratory findings supported the diagnosis of stage IE primary Hodgkin disease of the terminal ileum with Crohn disease.
Tuberculosis (TB) has been extensively described in association with various malignancies, especially Hodgkin disease (HD).
Conventional microscopy and immunohistochemical examination of the lymph node biopsy showed Hodgkin disease, mixed cellularity type.
Hodgkin disease primarily involving the colon without nodal disease has been described in the literature mostly as single case reports and occasionally as part of larger series.
The syncytial variant of nodular sclerosing Hodgkin disease is an unusual form of Hodgkin disease characterized microscopically by the more typical features of nodular sclerosis, as well as the presence of cohesive aggregates of atypical mononuclear Reed-Sternberg cell variants.