Top 10 Countries for Integral Membrane Protein
Research (ranked by number of senior researchers)
About X-Body Biosciences X-Body creates therapeutic antibodies against a wide variety of useful drug targets, and is primarily focused on integral membrane proteins
, such as GPCRs, ion channels, and transporters.
In contrast to proteins which usually exist in one of two incompatible conformations associated with water-soluble and integral membrane proteins
, PFTs show dimorphism in existing initially as water-soluble monomers and terminally as [beta]-barrel transmembrane oligomeric pores in the functionally active stage.
What they have to say about them includes native membrane protein versus yeast recombinant as demonstrated by the mitochondrial ADP/ATP carrier, the sarcoplasma calcium pump as an example of what can be learned about the function of a single protein from its various x-ray structures, two-dimensional crystallization of integral membrane proteins
for electron crystallography, observing both secondary and tertiary structure in membrane protein fragments, and a critical review of general guidelines for membrane protein model building and analysis.
While the restriction with regard to these limitations mentioned above is usually compensated for by particular biochemical techniques, mainly liquid chromatography tandem mass spectrometry (LC-MS/MS), exploiting LC-MS/MS for comparative investigations of integral membrane proteins
are currently raised (Wu and Yates, 2003).