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24) As a way to further simplify ART, current clinical trials are looking at 2-drug regimens including an integrase inhibitor with an NRTI, an INSTI, or an NNRTI, or a PI with one NRTI.
New integrase inhibitors like the daily-dosed dolutegravir are not yet available in SA, and the local price is as yet unknown.
Of the 229 people studied, 108 (47%) began therapy with a PI, 81 (35%) with an NNRTI, and 40 (18%) with the integrase inhibitor Isentress.
Hence, there is an urgent need to introduce newer antiretrovirals including newer class of potent drugs like integrase inhibitors in India.
ISENTRESSA (raltegravir), from MSD, was as Effective as Efavirenz at Suppressing HIV Viral Load and Increasing CD4 Cell Counts in Treatment-NaE[macron]ve Patients up to 144 Weeks When Used in Combination Therapy CAPE TOWN, South Africa--(BUSINESS WIRE)-- Not For Distribution To South African Journalists ISENTRESS A (raltegravir), an integrase inhibitor from Merck Sharpe & Dohme (MSD) was as effective as efavirenz at maintaining viral load suppression to undetectable levels (less than 50 copies/mL) and at improving CD4 counts in previously untreated (treatment-naE[macron]ve) patients through 144 weeks in a Phase II study still underway.
Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 857, 15-24.
has completed the Phase II clinical trial of GS 9137, a novel oral HIV integrase inhibitor.
s raltegravir, is an integrase inhibitor, which blocks viral genes from being incorporated into the host cell genome where they can be activated.
Iin fact, the strengthening of Avexa's internal clinical capabilities will complement the clinical phases of these programs, in particular Avexa's HIV integrase inhibitor program.
Fujiwara and his colleagues report they've found an integrase inhibitor, called S-1360.
However, a variety of technical problems have deterred the quest for an integrase inhibitor.