Mutation

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Related to JAK2 mutation: myelofibrosis, polycythemia, polycythemia vera

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
Carobbio A, Finazzi G, Guerini V, Spinelli O, Delaini F, Marchioli R, Borrelli G, Rambakh A, Barbui T: Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and JAK2 mutation status.
A JAK2 mutation also shows up in people with polycythemia vera, which is marked by abnormal red blood cell growth.
Coverage includes techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP 1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of acute myeloid leukemia by DNA- oligonucleotide microarrays, detection of the V617F JAK2 mutation in myeloproliferative disorders, gene rearrangements, FLT3 mutations andWT-1 overexpression.
4 Reimbursement for JAK2 Mutation Testing for Myeloproliferative Neoplasms 174 6.
In 2008, the World Health Organization (WHO) revised the diagnostic criteria for PV, ET, and PMF to reflect the significance of the JAK2 mutation.
Also, they pointed out that patients who inherited the JAK2 alteration were predisposed to acquiring another JAK2 mutation on the same DNA strand.