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virus
(redirected from JC virus)

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See: disease


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Although BK virus, JC virus, and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers.
It appears that natalizumab, by preventing the normal trafficking of lymphocytes, leads to unbridled JC virus replication contributing to the development of PML.
More than 3,000 patients who had been exposed to a mean of 18 monthly doses of natalizumab underwent evaluations, which included MRIs and testing of CSF for JC virus DNA.
 
 
 
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