| Progressive multifocal leukoencephalopathy (PML) PML results from reactivation of Jamestown Canyon virus (JC virus, JCV), infecting oligodendrocytes causing demyelination and gliosis [41]. Media from the positive cultures were tested by immunoassay for WNV, EEEV, Highlands J virus, Jamestown Canyon virus, La Crosse virus, Saint Louis encephalitis virus, and Flanders virus antigens, with specific monoclonal and polyclonal antibodies; results were negative. Eastern equine encephalitis virus, Cache Valley virus (8), and Jamestown Canyon virus (10) are the only human pathogens that have previously been isolated from naturally infected Ae. |
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