Some of the highlights include the concept of Kupffer cell
activation and the role of these cells in liver inflammation, oxidative stress--related injury, stellate cell activation, and liver fibrosis.
4]administration oxidant induced activation of kupffer cells
occur, with the release of proinflammatory cytokines like tumor TNF-[alpha], TGF-[beta] and IL-6.
Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell
polarization in mice.
As they also contain Kupffer cells
, there is uptake of the RE agents, resulting in marked signal intensity loss (Figure 7) that may be less than that of surrounding liver (30% in FNH vs.
Lead stimulates intercellular signalling between hepatocytes and Kupffer cells
The presence of several proliferative lesions in exposed mice, including multinucleated hepatocytes and oval and Kupffer cell
hyperplasia, in the absence of cellul ar necrosis or fibrosis, indicates an isolated proliferative response, and not a regenerative response following liver injury (Thoolen et al.
cytokine) called tumor necrosis factor alpha (TNF-[alpha]) from Kupffer cells
(Nakamura et al.
Compared with the normal liver tissues from the control group, in knockouts following LPS treatment significant evidence of injury with severe sinusoidal vascular congestion, mild neutrophilic infiltration and Kupffer cell
activation were demonstrated by some previous researchers (Konyalioglu et al.
Thus, it was hypothesized that Kupffer cell
activation by endotoxin derived from intestinal bacteria causes those cells to generate superoxide and TNF-[alpha], both of which can lead to tissue damage in the liver (see figure 1).
Activation of in vivo Kupffer cell
function by oral administration of Cordyceps sinensis in rats.
These findings confirm that the binding of endotoxin to its receptors on the Kupffer cells
and the resulting Kupffer cell
activation and production of TNF-[alpha] are key events in the development of alcoholic liver injury.
Endotoxin binds to Kupffer cell
receptors, initiating a cascade of events that lead to the release of a chemical messenger (i.