In DNs, all of the usual cellular components of normal liver parenchyma (hepatocytes, Kupffer cells
, and biliary ducts) are still found.
The response of the liver to ethanol and endotoxin is a complex process involving macrophage-like Kupffer cells
, hepatocytes, and stellate cells.
infilitrate liver tissue early after ischemia -reperfusion and partial hepatectomy.
Research funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA)/National Institutes of Health (NIH) first identified the importance of Kupffer cells
and their response to endotoxin in the progression of liver disease (Thurman et al.
These functional alterations were accompanied by some histological alterations, like congestion of the central vein, some polymorphonuclear inflammatory cells infiltrate, sinusoids walls showing numerous Kupffer cells
with swelling lumen by the blood cells (Figure 5).
Our findings were further supported by the histopathological examination of liver section, which illustrated that liver tissue of NDEA-treated rats showed drastic changes in the morphology of the liver cells, manifest as nuclear pleomorphism, intranuclear vacuoles, cellular infiltration, pyknotic nuclei and numerous Kupffer cells
Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells
(liver macrophages) in the blood pass through the hepatic sinusoids and in fibrosis become activated by adverse stimuli such as viruses or toxins.
37) Normal splenic tissue, as well as Kupffer cells
of the liver, predominantly filters these superparamagnetic iron oxides, rendering the contrast agent tissue specific.
Sato's team found that, while Kupffer cells
in the liver decompose endotoxin, the same cells also produce a substance called cytokines (TNF-alpha), which destroys surrounding cells in the liver and cause inflammation.
Eighty-five to ninety percent of all blood that leaves the stomach and intestines carries ingested substances directly to the liver, where macrophages (Greek for "big eaters") or Kupffer cells
remove large amounts of debris and bacteria.
Injected nanoparticulate systems are taken up by macrophages, mainly Kupffer cells
, after recognition by the complement system.