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The first studies of resveratrol in the early 2000s had suggested that it exerts some of its positive effects on health by activating SIRT1, also thought to be a longevity gene.
When food is scarce, FoxO factors shuttle from the cytoplasm back into the nucleus and activate longevity genes, which help the organism make it through lean times until food is available.
The findings, published online May 21 in the journal Aging, come from Einstein's Longevity Genes Project, which includes over 500 Ashkenazi Jews over the age of 95, and 700 of their offspring.
Resveratrol, he explains, appears to activate what are known as the sirtuin genes--sometimes referred to as scarcity or longevity genes.
Finding longevity genes is only one of many goals for gerontologists.
Even a strategy like calorie restriction, which has some interesting scientific basis, feeds into the weight loss and longevity frenzy when questionable future pills that will manipulate longevity genes are peddled prematurely.
We have identified many of the genes that regulate aging and the proteins encoded by these longevity genes are the targets of our drug discovery efforts.
Meanwhile, Thomas Perls of Harvard is hunting for longevity genes.
Genetic data for Ebert's paper was collected with support from NIH (T2D-GENES; Longevity Genes Project); the Medical Research Council and Wellcome Trust (Go-T2D); the Slim Initiative for Genomic Medicine in the Americas; and NHGRI, the National Heart, Lung, and Blood Institute and National Institute on Minority Health and Health Disparities (Jackson Heart Study).
Since its inception in 1998, Ellison's Medical Foundation has provided more than $300 million to fund basic biomedical research on aging, life span, and age-related diseases and disabilities--including telomeres, longevity genes, DNA and mitochondrial damage, Alzheimer's disease, neural development, degeneration, and cognitive decline, and more.
The findings come from Einstein's Longevity Genes Project, which includes over 500 Ashkenazi Jews over the age of 95 and 700 of their offspring.