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Mutation
(redirected from Loss-of-function)

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.



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2003) presented the results of an investigation of more than 16,000 genes for loss-of-function phenotypes in C.
By yielding direct and highly predictive insights into the cellular functions and loss-of-function phenotypes of analyzed genes, this RNAi-based approach will enable Merck to efficiently select targets with higher confidence for driving their drug development programs.
The method of identification, based on detailed analysis of RNAi-induced loss-of-function phenotypes in living human cells, conveys upon these targets a significantly stronger patho-physiological relevance than that typically seen for targets identified by less probative "first-wave" genomics methodologies of recent years.
 
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