When the scientists injected the mice with an antibody against the A-beta protein, prompting the rodents to produce fewer plaques, the microglial cells
resumed their normal functions.
Rapamycin treatment inhibits the hypoxia induced expression of inducible NO synthase in microglial cells
At 24 hr after IT DEP administration, immunohistochemical analysis showed that DEP up-regulated IBA-1 on microglial cells
, without obvious differences in morphology or cell number (Figure 3), a response similar to microglial activation previously observed in response to systemic LPS administration (Qin et al.
Moreover, all arimoclomol-treated groups tended to have a reduction in the number of apoptotic cells and microglial cells
compared to controls in the zone surrounding the lesion, again reaching statistical significance (p<0.
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and proinflammatory cytokine production in murine BV-2 microglial cells
Instead, scientists have accumulated evidence that HIV in the central nervous system mainly replicates inside two types of related cells: macrophages (scavenger cells that have migrated from the blood) and microglial cells
(the resident immune cells of the brain and spinal cord).
2008), reveal that CI/R-induced brain infarction developed along with microglial cell
activation and leukocyte infiltration in the infarct area which occurred in parallel with cerebral lipid peroxidation and protein nitrosylation in the damaged sites, indicating that oxidative and nitrosative stresses elicited by these inflammatory cells did contribute to the infarction.
2] cells, murine microglial cells
CdSe-MAA, Primary rat TOPO QDs hepatocytes QD micelles: Xenopus 5 x [10.
, as the brain's immune cells, constitute the active immune defense in the central nervous system (CNS).
Moreover, it inhibited lipopolysaccharide-induced nitric oxide formation and lipopolysaccharide-induced activation of the inducible isoform of nitric oxide synthase in rat microglial cells
(Fiebich et al.
The technique works by stimulating microglial cells
, which form part of the brain's immune system, to engulf and absorb the plaques.
These lipids fasten onto a molecule called a receptor on the surface of microglial cells