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A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012.
However, the method perfectly detected and differentiated variola from monkeypox virus (endemic in Africa), from cowpox virus (endemic in Europe but responsible for only limited cutaneous lesions in immunocompetent people), and also from vaccinia virus, thus helping to ascertain the diagnosis of complications of a smallpox vaccination in clinical practice (e.
Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001.
Transmissibility of the monkeypox virus clades via respiratory transmission: investigation using the prairie dog-monkeypox virus challenge system.
Although monkeypox virus (MPXV) can infect a wide variety of animal species when experimentally introduced, it is currently unknown which species are directly involved in its natural transmission cycle and whether [greater than or equal to] 1 species are responsible for MPXV perpetuation in nature (3).
In the past, ST-246 has demonstrated significant antiviral activity against both the monkeypox virus and smallpox virus in primate models of disease.
Real-time PCRs designed to differentiate orthopoxvirus species were performed, and samples were positive for VACV DNA but not for monkeypox virus DNA (5) (Table).
NASDAQ: SIGA) today announced that its lead smallpox drug, ST-246, has passed another milestone by demonstrating 100% protection against death in cynomolgus monkeys showing signs of infection with monkeypox virus as part of a primate trial conducted at the U.
Monkeypox virus (MPXV) is an orthopoxvirus and the causative agent for human monkeypox, a viral disease with clinical signs in humans similar to those seen in past smallpox patients (1,2).
It has already demonstrated significant antiviral activity in various animal trials, including the complete elimination of human smallpox virus or the related monkeypox virus in several primate studies.
Monkeypox virus occurs in western and central Africa, causes a disseminated infection in humans, can be transmitted among humans at a low rate, and is associated with a 1%-10% (depending on the virus strain) case-fatality rate.
In two additional primate trials, SIGA-246 afforded complete protection against the monkeypox virus, a closely related disease that is even more virulent in that species.