noted that the frequency of mutant alleles
strongly correlated with the prevalence of day 3 positivity after ACT treatment in humans in Cambodia and that those mutations reflected positive selection (6).
Up arrows indicate novel peaks from the mutant allele
Differentiation of normal and mutant alleles
of the Wx-B1 locus:
In fact, the dark-grown gametophytes with the dkg1 mutant allele
showed distinct negative gravitropism as compared with the gametophytes without the dkg1 allele (Fig.
Both genotypes (CG and GG) of mutant allele
(G) were found higher in patient group than in control group with a borderline significance (p=0.
So we can ask, "Is a rare, recessive mutant allele
more or less likely to survive against genetic drift, and will it take longer to increase under similar selective intensity (k)?
To eliminate a deleterious mutant allele
, like those responsible for cystic fibrosis or sickle cell anemia, could have some risk.
The CancerSelect gene panels achieve analytical sensitivity of more than 99% for mutations and indels at 2% mutant allele
One patient (ID PV04_584), who carried the W515L mutant allele
[G>T conversion decreasing the [T.
5 [micro]mol/l of one forward primer, specific for the mutant allele
(giving a 203 bp product) and 0.
We classified parasites as having A581G if the mutant allele
frequency was [greater than or equal to] 90% within the parasitemia level of the person.
In addition to providing a corporate summary, Payne will present data on selective silencing of transthyretin (TTR) V30M mutant allele
which is the causative agent of familial amyloidosis polyneuropathy (FAP), a rare disease with limited treatment options.