Mutation

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Related to Mutant proteins: conditional mutant

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
Prior to this work, it had not been clear if the human immune system could mount an effective response against mutant proteins produced by epithelial cell cancers and whether such a response could be used to develop personalized immunotherapies.
Zelboraf, however, is not for use in patients who lack the mutant proteins targeted by the drug, and the companion diagnostic test is essential for identifying which patients may benefit from therapy.
Crucially, the misfolded mutant proteins cause normal proinsulin proteins in beta cells to misfold as well, the scientists found in studies of mouse and rat beta cells.
In the March Neuron, Junying Yuan of Harvard Medical School in Boston and her colleagues report that certain features of the mutant proteins made in Huntington's disease, so-called polyglutamine repeats, help activate one of the many caspases found in mammalian cells.
Rett syndrome could indeed prove the Rosetta Stone, allowing scientists to develop techniques for understanding the effects of other mutant proteins that affect neurons," said Dr.
The new research shows that normal synaptic receptor activity makes nerve cells more resistant to the mutant proteins.
Patent for its novel method of restoring normal function to mutant proteins with therapeutic pharmacological chaperones.
Similarly, when scientists last year found that people with neurodegenerative disorders such as Huntington's disease have brain cells stuffed with unusual clumps of mutant proteins, many simply assumed that the abnormal buildup inside the cells' nuclei caused the cell death characteristic of the illnesses (SN: 8/16/97, p.
The researchers then produced a variety of mutant proteins in order to test the functional structure of the enzymes.