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However, the myasthenic patient may experience a sudden worsening of symptoms in the intercostal and diaphragmatic muscles (12) during drug treatment, causing a real emergency: myasthenic crisis (decreased stimulation of AchR), which may require oro-tracheal intubation for survival.
If the patient improves, a myasthenic crisis has occurred and the dose of the medication must be increased.
About 10% of MG patients develop a life-threatening weakness of the respiratory muscles needed for breathing, a condition called myasthenic crisis.