Mutation

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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
Sequence screening of all the family members showed a nonsense mutation at nucleotide position c.
Biopharmaceutical company PTC Therapeutics (NasdaqGS:PTCT) reported on Tuesday the initiation of a rolling submission of a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for Translarna for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD).
11) Unlike mutations in other tumor suppressor genes, which are most often characterized by nonsense mutations that result in a truncated or null protein, most TP53 mutations are missense mutations that result in amino acid substitutions.
M2 EQUITYBITES-December 24, 2014-PTC Therapeutics begins rolling submission of Translarna's NDA to the US FDA for treating nonsense mutation Duchenne muscular dystrophy
Translarna is a protein restoration therapy designed to enable the formation of a functioning protein in patients with genetic disorders caused by a nonsense mutation, such as Duchenne muscular dystrophy.
Mutational analysis of the patient's tumor showed 2 RB1 mutant alleles: a nonsense mutation c.
Patient 56 harbored a c54C>A transversion originating the nonsense mutation Ser185X (TGC changes to stop codon TGA), which predicts a truncated protein consisting of only 185 amino acids.
The drugs, evaluated under the Highly Specialised Technology Programme of the National Institute for Health and Care Excellence (NICE), will be made available to patients with very rare conditions including atypical Haemolytic Uraemic Syndrome, mucopolysaccharidosis type IVa and Duchenne muscular dystrophy caused by a nonsense mutation.