Mutation

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Related to Null mutation: frameshift mutation

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
Finally, preclinical mouse models using either mice with a null mutation for TRPV4 or wild-type mice treated with a TRPV4 antagonist demonstrated increased thermogenesis in brown/beige fat tissues and protection from diet-induced obesity, inflammation and insulin resistance.
About 1 in 10 individuals of European ancestry carry one FLG null mutation, meaning that such individuals have only about half of the normal FLG protein in their skin, resulting in dry skin and/or ichthyosis vulgaris and a high risk for AD.
A similar pattern of vascular calcification was observed in FH heterozygotes (due to a null mutation of the LDLR), but was delayed by approximately 20 years in heterozygotes compared with homozygotes (6).
To evaluate the association between PCBs and GSTM1 null mutation and their impact on the risk of endometriosis, the present study was undertaken to assertion whether women with endometriosis having higher concentrations of PCBs were more prone to carry GSTM1 null mutation compared to those free from the disease.
An importance of the gene was confirmed in transgenic mice experiments--mice homozygous for a null mutation in the PRLR gene were sterile due to a failure of embryonic implantation, demonstrated irregular cycles, reduced fertilization rates and defective embryonic development (Ormandy et al.
Alturas has peak Rapid Visco-Analyzer flour viscosity similar to partial waxy genotypes Centennial and Penawawa and likely carries the null mutation for Wx-B1 derived from its parent Centennial (Guttieri et al.
RNAi uses short dRNA oligo-nucleotides to regions of expressed portions of genes to phenocopy a null mutation.
The ttx-3 null mutation causes the same behavioral defect as laser ablation of AIY, implying that AIY does not signal in this mutant (5).
Factor V null mutation affecting the Roche LightCycler factor V Leiden assay [Technical Brief] Clin Chem 2005;51:1533-5.
A novel factor V null mutation at Arg 506 causes a false positive factor V Leiden result.