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2) In addition to screening tests for toxins, calculation of the osmolal gap (OG) as osmolality - (2[Na+] + [urea] + [glucose]), may be helpful as an indicator of intoxication.
Anion and osmolal gaps in the diagnosis of methanol poisoning: clinical study in 28 patients.
3 (B) Serum bicarbonate < 20 meq/L (C) Osmolal gap > 10 mOsm/L (D) Urinary oxalate crystals present (in the case of EG poisoning) Data are from the American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Ethylene Glycol and Methanol Poisoning.
3 mmol/L; anion gap, 14 mmol/L; and osmolal gap, 72 mOsm/kg.
The increased osmolal gap observed in this case could not be explained by ethanol alone.
Osmolal gaps and osmolality for healthy and ED patients in 1998 and 2007-2009.
Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap.
Background: The osmolal gap (OG) is a screening test for the detection of toxic volatiles such as methanol and ethylene glycol.
measurement of the serum or plasma osmolality and calculation of the osmolal gap, have been studied as alternatives to direct assays of these alcohols (55,56).