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Secondary immune system organs include: the spleen, a conference center and an emergency storage depot for blood; the tonsils, which guard the entrance to the throat; the appendix, which samples material passing through the intestines; the approximately 100 lymph nodes, which serve as sieves or strainers to filter lymph fluid and thus guard various parts of the body; and Peyer's patches, special lymph glands that function similarly to the appendix. Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. Although integrins are not present on the apical surface of enterocytes, they are located on the apical surface of microfold cells found in Peyer's patches along the intestinal lumen (18). |
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