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1993) examined the use of a combination of calcium and magnesium carbonate as a phosphate binder in patients on continuous ambulatory peritoneal dialysis (CAPD) for a one-year period.
Studies that compare sevelamer and lanthanum with calcium-based phosphate binders demonstrate similar effectiveness at lowering serum phosphorus.
The oral powder formulation was developed by Shire to give patients more choice in how they take their phosphate binder.
Genzyme says Renvela is a next generation version of Renagel, a calcium-free, metal-free, non-absorbed phosphate binder, and has the added benefit of a carbonate buffer.
et al, The use of Renalzin, a new intestinal phosphate binder, in feline chronic renal failure.
While being severely restricted in fluid intake, CKD-5D patients take on average 10-14 oral medications each day, including 9 or more phosphate binder pills.
Zerenex (ferric citrate), a ferric iron-based phosphate binder, is currently in Phase 3 clinical development in the United States for the treatment of hyperphosphatemia (elevated phosphate levels) in patients with end-stage renal disease on dialysis which is being conducted under a Special Protocol Assessment (SPA) agreement with the FDA.
Lanthanum carbonate is indicated as a phosphate binder in patients with stage 5 chronic kidney disease (Anon, 2007).
Renvela is a next-generation version of the company's Renagel, the most-prescribed phosphate binder in the US.
Similar to the phosphate binder market, nephrologists reported initiating vitamin D at a mean iPTH level of 155pg/dL but the audited levels were significantly higher with 85 percent of patients initiated when iPTH levels exceeded 100pg/dL.
Auryxia is the first and only absorbable-iron-based phosphate binder that is clinically proven to effectively control phosphate levels within the KDOQI guidelines range of 3.