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inhibitor |
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The HCC biomarkers cytokeratin 8 and plasminogen activator inhibitor 1 (PAI-1) were all significantly increased in arsenic-induced HCC, and also higher in arsenic-exposed tumor-surrounding tissues. It also measured levels of plasminogen activator inhibitor, PAI-1, which dissolves TPA, acting as a balance against too much of the anti-clotting enzyme. Sobel found that 47 percent of those heart attack victims studied had "markedly elevated" blood levels of the plasminogen activator inhibitor (PAI-1) that inactivates tPA, and that those levels stayed high for 24 hours after tPA treatment stopped. |
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